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However one should keep in mind that
2024-11-12
However, one should keep in mind that these results may not reflect exactly in vivo antioxidant activity. Many other issues such as absorption, metabolism and physicochemical properties of different antioxidants must also be considered (Prior et al., 2007, Wu et al., 2004). Some research groups are
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In conclusion there are only a few experimental reports eval
2024-11-12
In conclusion, there are only a few experimental reports evaluating the influence of Myriocin on allergy. With the exception of studies using macrolides, most point to their harmful effect on the severity of this disease. Future studies will be crucial to define the impact of antibiotic use on alle
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Perhaps the first evidence of
2024-11-12
Perhaps the first evidence of AMPKs therapeutic ability in DM1 came from Thomas Cooper’s laboratory where they demonstrated that insulin-independent glucose uptake was unaffected in human DM1 muscle Celastrol receptor treated with MET, an AMPK activator and first-line therapy for type 2 diabetes me
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ap5 br Experimental procedures br Results br Discussion
2024-11-12
Experimental procedures Results Discussion Acknowledgments SRE and EBL contributed equally to this ap5 work. SRE, EBL, and MJT designed experiments, SRE, EBL, MCH, and AEI conducted experiments, SRE and EBL analyzed data, and EBL and MJT wrote the manuscript. We would like to thank Dr. M
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We next developed a system for
2024-11-12
We next developed a system for staging severity. Our guiding principles were the following. Two types of information about the research participant are staged independently from each other: (1) grading disease severity using biomarkers and (2) grading the severity of cognitive impairment. Measures u
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An ALK rearrangement was found in all the
2024-11-12
An ALK rearrangement was found in all the analyzable ‘truly positive’ IHC+/FISH+ samples, and the proportion of the various transcripts was in accordance with the literature [[26], [46], [47], [48]]. In these samples, the RNA-seq technique was therefore 100% sensitive and specific. Additional non-ta
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By promoting bundling and processive elongation of actin fil
2024-11-12
By promoting bundling and processive elongation of NECA filaments and inhibiting association of capping protein with filament barbed ends, Ena/VASP family proteins contribute to the dynamics of lamellipodia and filopodia [41] and maintenance of focal adhesions and tight junctions [42, 43]. According
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PC is considered as a
2024-11-12
PC is considered as a cancer of the epigenome (Grasso et al., 2012, Robinson et al., 2015). Our results demonstrate that the interaction of AR with ACK1 drives the positive feedback epigenetic circuitry that is ultimately conducive to promote AR transcription. Further, this circuitry subjugates AR t
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epacadostat An AXL decoy receptor with enhanced GAS binding
2024-11-11
An AXL decoy receptor with enhanced GAS6-binding properties, MYD1, was engineered as a therapeutic tool to disrupt GAS6/AXL signaling in vivo (Kariolis et al., 2014). MYD1 was shown to block metastasis of human ovarian cancer epacadostat and a murine breast cancer cell line in grafting assays in mi
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Many reports have well documented that signaling pathways
2024-11-11
Many reports have well documented that signaling pathways play a pivotal role in controlling longevity. The most studied of these pathways is the IGF-1 pathway [11,12]. A disruption of this pathway has been found to extend longevity in different groups of species starting from Caenorhabditis elegans
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Several mechanisms have been suggested to account for the
2024-11-11
Several mechanisms have been suggested to account for the causal association of ICAM-1 induction and leukocyte adhesion with DR, including oxidative stress [16], NF-κB [17], PKC [18], and bioactive lipids [19]. Our previous studies highlighted the role of bioactive lipid metabolites derived from 12/
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Atherosclerosis is a chronic lipid metabolism disorder linke
2024-11-11
Atherosclerosis is a chronic lipid metabolism disorder linked with lipid accumulation within the arterial wall and subsequent formation of foam cells and vascular disease [96], [97]. The level of apelin is decreased in human atherosclerotic coronary arteries [4], and coronary collateral formation in
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br Materials and methods br Results br
2024-11-11
Materials and methods Results Discussion Pulmonary fibrosis is a progressive and chronic lung disease and its typical features include ep4 proliferation, epithelial injury, chronic interstitial inflammation, increased extracellular matrix (ECM) production, and collapse of alveoli, all of w
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Bran is a byproduct of
2024-11-11
Bran is a byproduct of flour milling, typically utilized as a valuable component of animal feeds. Because of its attractive technological and health-promoting properties, it BMS354825 has also been increasingly used in food manufacturing as a source of dietary fiber. Indeed, with the growing intere
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First the complete canonical brain original RAS
2024-11-11
First, the complete canonical brain original RAS (Angiotensinogen, Renin, Angiotensin I, Angiotensin Converting Enzyme (ACE), Angiotensin II) has not been conclusively identified in any specific cell type within the brain [1]. Validated evidence for the presence of brain Angiotensinogen and ACE was
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