• We demonstrate a role for low oxygen to regulate ATX

  2023-08-21

  

  We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 ganciclovir mg and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX mRNA

• Loss of expression or functional activity

  2023-08-21

  

  Loss of expression or functional activity of cell adhesion is intricately related to advanced stages of tumour progression and invasiveness. Martin-Belmonte and Perez-Moreno recently mentioned that the deregulation of adhesion can alter tumourgenesis in the early stage. We have shown for the first t

• Thiol are reduced by two major redox systems glutathione glu

  2023-08-21

  

  Thiol are reduced by two major redox systems, glutathione/glutaredoxin (GRX) and thioredoxin (TRX), which have been extensively studied in plants [13], [14], [15]. Glutathione, a thiol-containing tripeptide, exists in a reduced (GSH) or an oxidized form (GSSG). It has a major role as a redox buffer.

• Despite extensive studies on the expression of T pallidum in

  2023-08-18

  

  Despite extensive studies on the expression of T. pallidum-induced pro-inflammatory cytokines, very little is known about T. pallidum-mediated intracellular signaling pathway activation, that leads to cytokine expression in macrophages. A network of signaling molecules, transcription factors, epigen

• br ABCA modulates intracellular sphingolipid metabolism in t

  2023-08-18

  

  ABCA2 modulates intracellular sphingolipid metabolism in the LE/LY Recycling of plasma membrane lipids that occurs by constitutive endocytosis and vesicularization of complex glycolipids, complex sphingolipids and cholesterol as well as free cholesterol liberated from LDL after receptor-mediated

• eg5 In this scenario the receptor tyrosine kinase inhibitors

  2023-08-18

  

  In this scenario, the receptor tyrosine kinase inhibitors (TKI), sunitinib, an anti-angiogenic agent, was tested in phase III trial, leading to a longer progressing free survival when compared to interferon (median: 11 vs. 5mo, respectively, hazard ratio (HR) = 0.42; 95% CI: 0.32–0.54; Peg5 in a co

• Five alternatively spliced isoforms of ATX have been describ

  2023-08-18

  

  Five alternatively-spliced isoforms of ATX have been described and all are catalytically active [16], [17]. The original ATX described in 1992 is termed ATXα, whereas the most abundant isoform is ATXβ and is the same isoform responsible for plasma lysoPLD activity [18]. Full length ATX is synthesize

• ddhGTP Several in vivo and in vitro studies have demonstrate

  2023-08-18

  

  Several in vivo and in vitro studies have demonstrated changes in bioactive lipid profiles under hyperglycemic conditions and have linked these changes with increased leukocyte adhesion and vascular dysfunction during diabetes. This input has originated partly from lipidomic studies that showed elev

• Although the LB domains of

  2023-08-18

  

  Although the LB2 domains of mGlu receptors have not been shown to form an extensive interface during activation, they do draw closer to each other, as demonstrated in crystal structures (Kunishima et al., 2000, Muto et al., 2007, Tsuchiya et al., 2002) and by FRET analysis (Doumazane et al., 2013, V

• Cyclopiazonic acid The neural circuitry involved in the prod

  2023-08-18

  

  The neural circuitry involved in the production of the EOD, its modulations, and in the sensory processing of communication signals has been well characterized (Bell and Maler, 2005; Chacron et al., 2011; Krahe and Maler, 2014; reviewed in Metzner, 1999). Pacemaker cells located in the pacemaker nuc

• APJ receptors have a amino acid sequence with

  2023-08-18

  

  APJ receptors have a 380 amino Caspase-1, human recombinant proteinase sequence with a characteristic G-protein structure, including seven transmembrane domains and post-translation modification sites for phosphorylation, palmitoylation and glycosylation along with association sites for β-arrestin (

• Obesity is associated with chronic low grade inflammation

  2023-08-18

  

  Obesity is associated with chronic low-grade BIIE 0246 resulting from increased M1 macrophage infiltration into adipose tissue, which can subsequently lead to the development of insulin resistance. Previously, we reported that LFE and FSB both reduced body weight gain in high fat diet-induced obese

• br Materials and method br Results and discussion br

  2023-08-18

  

  Materials and method Results and discussion Conclusion The adsorption behaviors of 5 antibiotics on 5 types of microplastic particles were investigated using batch type experiments. Our results showed that adsorption capacities varied among antibiotics, plastic types, and environmental cond

• Interestingly we noticed that LPS exposure was associated

  2023-08-17

  

  Interestingly, we noticed that LPS exposure was associated with decreased phosphorylation of AMPK and increased phosphorylation of p70S6K1, suggesting that AMPK inactivation and the subsequent mTOR activation might be involved in the development of LPS-induced inflammation. On the other side, treatm

• DLPC synthesis br Acknowledgments The authors thank Claudia

  2023-08-17

  

  Acknowledgments The authors thank Claudia Wittrock for her excellent technical assistance. The work was supported by grants of the Deutsche Forschungsgemeinschaft (SFB974 TP B05) and of the Anton-Betz-Stiftung to N.K. A.M. is an associate member of the iBrain graduate school at the University of

15474 records 309/1032 page Previous Next First page 上5页 306307308309310 下5页 Last page