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Formation of SAHFs in human cells is
2024-07-25
Formation of SAHFs in human Amrubicin is a dynamic and multifaceted process that is largely dependent on the p16/pRB ras-induced senescence pathway [108]. Many details remain to be elucidated but formation appears to be driven by a complex of histone chaperones (HIRA and ASF1a), a pRB/hBrm/HDAC1/HP
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Interest in natural products has led to the study
2024-07-24
Interest in natural products has led to the study of plant extracts as sources of ARIs. However, chemical complexity of natural extracts makes the identification of ARIs challenging and time-consuming. Identification of bioactive compounds with the desired biological effect from natural products, co
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br Materials and methods br Results
2024-07-24
Materials and methods Results Discussion Conclusions These studies provide important mechanistic insights to explain the long-established physiological observation that obese adipose tissue has higher rates of basal lipolysis. Increased lipolysis contributes to increased hepatic Acetamin
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Pasireotide The literature suggests that adiponectin
2024-07-24
The literature suggests that adiponectin has a steroidogenic effect on ovarian function. In pigs, in vitro studies have shown that adiponectin reduced basal testosterone secretion in internal theca cells; in granulosa cells, it increased secretion of estradiol and, in combination with insulin, incre
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The disease stimulatory effects of
2024-07-24
The disease-stimulatory effects of hyperadiponectinemia in patients contradict a previous view based on studies of preclinical models showing that APN might be beneficial for AD [8]. Indeed, despite the action of APN as a risk factor in patients with AD, APN is protective against oxidative stress-in
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br Experimental section br Results and discussion br
2024-07-24
Experimental section Results and discussion Conclusions We present a simple, sensitive and selective assay of ADA activity and its inhibitor using the enzyme catalyzed reaction and the different interaction intensity of dye-labeled AD aptamer, aptamer/AD complex with GO. The as-proposed met
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The UV vis and fluorescence spectra have been used to
2024-07-24
The UV–vis and fluorescence spectra have been used to study the interaction between small chemical molecules and biomolecules (Punith and Seetharamappa, 2012). The UV DTP3 peak of the protein changes with the microenvironment of the chromophore. That is, the peaks may show a certain degree of red s
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Sulfo-NHS-LC-Biotin synthesis br STAR Methods br Author Cont
2024-07-24
STAR★Methods Author Contributions Acknowledgments We thank Antony M. Dean for initial discussions and encouragement concerning ancestral sequence reconstruction. We also thank Natalie K. Goto for constructive criticism concerning the manuscript, Steven M. Sine for providing Sulfo-NHS-LC-Bio
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If the lack of specificity
2024-07-24
If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it ASA404 may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic interventions such as limited c
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br ACL Regulation and Role in Lipid Metabolism ACL is
2024-07-24
ACL Regulation and Role in Lipid Metabolism ACL is a ubiquitous enzyme at the nexus of nutrient catabolism and synthesis of cholesterol and fatty acids. In mammals, it is highly expressed in lipogenic tissues including adipose, liver, and lactating mammary glands [9]. In the presence of ATP and C
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Unfortunately results of serum plasma
2024-07-23
Unfortunately, results of serum/plasma AC assessment after food antioxidant intake are rather controversial: although some papers reported an increase of AC after food antioxidant intake (Khan et al., 2015, Torabian et al., 2009), unexpectedly, in a lot of long-term intervention studies (days, weeks
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We further conducted stratified analyses to observe changes
2024-07-23
We further conducted stratified analyses to observe changes in enzyme levels across the periods by subgroups. Fig. 1 shows the changes in GPx levels by subgroups of age, sex, and smoking status. In all participants, GPx levels decreased when air pollution levels declined but increased after the Olym
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Introduction It has long been recognized that angiogenesis
2024-07-23
Introduction It has long been recognized that angiogenesis is critical to the growth, progression, and metastasis of many solid tumor types [1], and thus, drugs targeting the angiogenic pathway have been a topic of clinical investigation in the oncology community for many years. Angiogenesis is reg
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Intracellular Signaling Cascades From ligand
2024-07-23
Intracellular Signaling Cascades. From ligand sensitization to translation of genes, all cellular processes are dependent on the intracellular levels and activity of partners involved in the signaling pathway. These signaling events lead to critical post-translational modifications including phospho
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br Acknowledgments br Introduction Amyloid deposit
2024-07-23
Acknowledgments Introduction Amyloid deposit formation is defined by the aggregation of β-sheeted forms of proteins that appear as starch-like amorphous material [1], [2]. Using a Kongo red stain, amyloids show birefringence behavior and an apple-green to reddish multicolor emission. Extracere
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