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br Materials and methods br Results
2020-02-17
Materials and methods Results Discussion In general, CI symptoms are often visible only after the chilled products have been removed from coolstore to a warmer temperature (Schirra and Cohen, 1999). However, in the present work, \'satsuma’ mandarin fruit stored at 2°C showed chilling sympto
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While a growing body of knowledge demonstrates the
2020-02-17
While a growing body of knowledge demonstrates the importance of COX-1 and COX-2 accompanied with neuroinflammation in altitude related conditions. In fact, PGE2 has been widely thought to promote the neuronal inflammation and degeneration in many neurological maladies (Griffin et al., 2013, Jiang a
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There are studies that evaluated the stability of CMV
2020-02-17
There are studies that evaluated the stability of CMV DNA over different periods of time. A study that evaluated stability of EDTA plasma samples stored over a 21-day period at 4 °C found no significant change in the viral loads or any trend of continued DNA degradation [9]. Another study did not fi
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br Funding This work was supported by intramural funding of
2020-02-17
Funding This work was supported by intramural funding of the Department of Internal Medicine I-Cardiology, University Hospital Aachen, RWTH Aachen. Acknowledgments Introduction Cyclic adenosine monophosphate (cAMP) is a central second messenger that controls a plethora of vital functions.
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Finally we have determined for
2020-02-15
Finally, we have determined for the first time that aromatase enzyme activity is necessary to observe IGF-1-dependent BMH-21 mg receptor activation. Neuroestrogen synthesis has been shown to be important for the maintenance of synaptic spine density in hippocampal slice cultures (Kretz et al., 2004
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br Conclusion As far as we know this work constituted
2020-02-14
Conclusion As far as we know, this work constituted the first use of silver nitrate staining and sequential FISH in V. vinifera. This technique allowed the unequivocal identification of Ag-NORs and corresponding rDNA loci. Besides, silver nitrate staining and sequential FISH may bring new insight
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The unique property of mutant IDH in producing an oncometabo
2020-02-14
The unique property of mutant IDH1/2 in producing an oncometabolite that has no known physiological function makes mutant IDH enzymes as obvious potential therapeutic targets for the treatment of IDH-mutated tumors (Rohle et al., 2013, Wang et al., 2013). Clinical studies have also suggested the pre
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ach receptors br Results br Discussion The structures presen
2020-02-14
Results Discussion The structures presented here were solved at high ach receptors and show in detail how DDR1 achieves high affinity for imatinib and ponatinib, respectively. Both type II inhibitors bind in their more potent extended conformations to the inactive DFG-out conformation of the
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Our study demonstrated that the sequential events
2020-02-14
Our study demonstrated that the sequential events of PKA and AMPK activation were involved in kinsenoside-mediated lipolysis. Within 1 h, PKA transiently inhibited AMPK activation by mitigating LKB1-mediated AMPK phosphorylation at Thr172, and PKA reduced AMPK-mediated phosphorylation at HSL-Ser565
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br Discussion br Conflicts of interest br Acknowledgment br
2020-02-14
Discussion Conflicts of interest Acknowledgment Introduction Ewing\'s sarcoma (EWS) is a bone cancer arising mostly in children. In 1921, EWS was originally described as “diffuse endothelioma of bone” by Dr. James R. Ewing, an American pathologist [1]. In 1992, Ewing sarcoma breakpoint r
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ATP binding cassette transporters such as
2020-02-14
ATP-binding cassette transporters such as ABCA1 and ABCG1 are expressed on cell membranes to transport cholesterol from Aurora Kinase Inhibitor III mg to HDL. These transporters help to improve RCT and reduce atherosclerosis. ABCA1 and ABCG1 gene expression are primarily induced by the stimulation
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In summary our findings show that LPS can activate CysLT
2020-02-13
In summary, our findings show that LPS can activate CysLT2R on microglial DOI hydrochloride mg to induce microglial inflammation and microglia-dependent neuronal death. Furthermore, pharmacological inhibition or knocking down of CysLT2R expression protects neurons against neurotoxicity via suppress
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br Material and methods br Results br
2020-02-13
Material and methods Results Discussion The present study shows that peripheral administration of the nonpeptidic corticotropin-releasing factor CRF1 receptor antagonist CP-154,526 before a social defeat inhibits the development of CPP induced with a subthreshold dose of cocaine and reverse
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br Conclusion br Acknowledgement The
2020-02-13
Conclusion Acknowledgement The project was supported by National Natural Science Foundation of China, China (No. 31872535); Natural Science Foundation of Shandong Province, China (ZR2018MC027, ZR2016CQ29); and Funds of Shandong \"Double Tops\" Program, China. Introduction High-altitude hyp
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In humans individual differences in prefrontal
2020-02-13
In humans, individual differences in prefrontal dopamine are partially caused by the Val158Met single-nucleotide polymorphism on the catechol-O-methyltransferase gene (COMT). This gene controls activity of the COMT enzyme, which degrades extracellular catecholamines including dopamine. The Val varia
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