• Stable isotope studies applied to skeletal

  2020-03-07

  

  Stable isotope studies, applied to skeletal remains of early Pacific populations, have shown a trend toward a horticultural diet with temporal variation in response to local environmental conditions (Field et al., 2009; Kinaston and Buckley, 2013; Valentin et al., 2010, Valentin et al., 2014; Kinast

• br Methods br Results br Discussion There are

  2020-03-07

  

  Methods Results Discussion There are two particularly important facets of the present ERK findings relevant to drug conditioning. One is the strong ERK signal observed in the medial prefrontal cortex and the nucleus accumbens during the immediate post-trial interval following the final cond

• br Significance Our understanding of the ubiquitin biology

  2020-03-07

  

  Significance Our understanding of the ubiquitin biology has been rapidly expanding. The role of the ubiquitin system in the pathogenesis of numerous disease states has increased the interest in finding new strategies to pharmacologically interfere with the enzymes responsible of the ubiquitinatio

• br Acknowledgements The research leading to these results

  2020-03-07

  

  Acknowledgements The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7-PEOPLE-2013-COFUND) under grant agreement no 609020 − Scientia Fellows (JB) and the Research Council of Norway (NFR-grant 221444) (JB, JPM, OB). Introduction Hu

• br Materials and methods br Results br Discussion We

  2020-03-07

  

  Materials and methods Results Discussion We found that mRNA expression of PCNA significantly was down-regulated in BCP-ALL NK 252 australia following co-treatment with doxorubicin and NU7441 (Fig. 6e). Our result is congruent with Gehen et al. study reporting that down-regulation of PCNA p

• br Diacylglycerol kinases and T cell responses

  2020-03-07

  

  Diacylglycerol kinases and T cell responses Diacylglycerol kinases and cancer Several studies implicate DGKα in tumor progression, but its function is debated, as it might also have roles as a tumor suppressor. Diminished DGKα expression is linked to malignant transformation in epithelia. High

• Real time PCR as described

  2020-03-07

  

  Real-time PCR, as described previously with minor modifications, was used to detect DNA . The PCR mixture (Qiagen) was as follows: 5mM MgCl2, 2.5μl of 10x PCR Buffer, 0.125μl of HotStarTaq DNA Polymerase, 0.25mM of each dNTP, 0.4μM of each primer and 0.1μM of FAMlabelled probe (‘5-aacaattggagggcaag

• Films treated with Diaz ES VWFIIINle but not exposed to

  2020-03-07

  

  Films treated with Diaz-ES-VWFIIINle but not exposed to UV light supported only slight platelet deposition, suggesting that passively-bound peptides were removed under shear. However, treatment with Diaz-ES-VWFIIINle and UV restored platelet surface coverage to about 50% of the level on native colla

• Other karyopherins besides CRM must bind to FG Nups

  2020-03-07

  

  Other karyopherins besides CRM1 must bind to FG-Nups in a similar fashion. However, at an atomic resolution, only the interaction of importin β with isolated FG motifs has been analyzed (Bayliss et al., 2000, Bayliss et al., 2002, Liu and Stewart, 2005). Despite similarities in the FG-binding pocket

• br Experimental Procedures br Acknowledgments br Introductio

  2020-03-06

  

  Experimental Procedures Acknowledgments Introduction Incessant consumption of fossil fuels brings on global energy crisis and serious environmental concerns. Hence, the researchers have paid considerable attention to alternative renewable bioenergy. Microalgae has been considered as potenti

• The CysLT receptor antagonist BayCysLT RA significantly supp

  2020-03-06

  

  The CysLT2 receptor antagonist BayCysLT2RA significantly suppressed multiple antigen challenge-induced infiltration of eosinophils and mononuclear CPTH2 hydrochloride into the lung, indicating that CysLT2 receptor activation is involved in leukocyte migration. In contrast to the present finding, Ba

• br Conclusion In conclusion the current study showed that

  2020-03-06

  

  Conclusion In conclusion, the current study showed that central CRF signals have crucial roles in behavioral changes, such as locomotor activity and anxiety behavior. In contrast, the hormonal regulation of CRF through HPA axis can be primarily modulated at the peripheral level. CRF1 receptor ant

• Bearing in mind that temperamental traits are genetically de

  2020-03-06

  

  Bearing in mind that temperamental traits are genetically determined, in the present study we have chosen to investigate COMT and OPRM1 gene polymorphisms related to stimulation of the nervous system, which is extremely important in combat sports. The μ-opioid receptor gene OPRM1 is located on the

• In this study we detected the PAX FOXO fusion

  2020-03-06

  

  In this study, we detected the PAX3/7–FOXO1 fusion Fructose in 50% of the ARMS samples, 40% PAX3–FOXO1 and 10% PAX7–FOXO1. This detection confirmed the histological diagnosis and adds to its new information that can be useful in the prognosis evaluation of ARMS patients, since the patients with PAX

• br Materials and methods br Results br

  2020-03-06

  

  Materials and methods Results Discussion ParI, the first C5-DNA-MTase from a psychrophilic bacterium to be characterized, displays DNA methylation activity in vivo and in vitro. Its biophysical characteristics are consistent with large regions of disorder including thermal unfolding transit

15331 records 890/1023 page Previous Next First page 上5页 886887888889890 下5页 Last page