• Unraveling Apoptosis in Tumor Microenvironments with One-...

  2025-09-28

  Discover how the One-step TUNEL Cy3 Apoptosis Detection Kit enables precise apoptosis detection in complex tumor models. This article explores advanced applications in tumor microenvironment research, offering insights beyond standard DNA fragmentation assays.

• CB-5083: Advanced Insights into Selective p97 Inhibition ...

  2025-09-27

  Explore how CB-5083, a potent oral p97 inhibitor, uniquely disrupts protein and lipid homeostasis to induce cancer cell apoptosis and tumor growth inhibition. This article provides a deeper mechanistic and translational perspective, distinguishing itself from prior reviews.

• 2'3'-cGAMP (sodium salt): Unraveling Endothelial-Immune C...

  2025-09-26

  Explore how 2'3'-cGAMP (sodium salt) enables advanced investigation of endothelial-immune crosstalk within the cGAS-STING signaling pathway. This article uniquely highlights its role in orchestrating tumor vasculature normalization and antiviral responses, setting it apart in immunotherapy research.

• Bufuralol Hydrochloride: Advancing β-Adrenergic Research ...

  2025-09-25

  Explore how Bufuralol hydrochloride, a non-selective β-adrenergic receptor antagonist, is transforming cardiovascular pharmacology research through innovative approaches to β-adrenergic modulation studies and signaling pathway analysis. Discover unique insights into its mechanistic roles, membrane-stabilizing effects, and translational potential in disease modeling.

• Influenza Hemagglutinin (HA) Peptide: Precision Tag for D...

  2025-09-24

  Explore the Influenza Hemagglutinin (HA) Peptide as an advanced molecular biology peptide tag for dissecting dynamic ubiquitination and protein interaction networks. This in-depth article unveils the unique advantages of the HA tag peptide in mechanistic cancer research and high-specificity immunoprecipitation workflows.

• Phenacetin in Non-Opioid Analgesic Research: Solubility a...

  2025-09-23

  This article examines Phenacetin (N-(4-ethoxyphenyl)acetamide) as a model non-opioid analgesic in scientific research, focusing on its solubility, pharmacokinetic applications, and safety profile. We highlight methodological advances and provide technical guidance for researchers utilizing Phenacetin in intestinal organoid systems.

• br Conclus o br Conflitos de interesses br Alzheimer

  2025-03-03

  

  Conclusão Conflitos de interesses Alzheimer Disease: Common and Complex Alzheimer’s disease (AD) is a genetically complex, multifactorial disease that leads to neurodegenerative dementia. There is no cure for AD yet, and due to a high prevalence and continuously increasing incidence it pose

• Many of the cellular processes

  2025-03-03

  

  Many of the cellular processes regulated by AKT activation are also controlled by other intracellular pathways such as the MAPK pathway, the PLCγ pathway, but also, directly or indirectly, by signaling pathways not linked to RTK transmembrane receptors, such as growth factor-linked signaling affecti

• br AHR mediates TCDD toxicity and wasting syndrome

  2025-03-03

  

  AHR mediates TCDD toxicity and wasting syndrome TCDD causes numerous toxicities in laboratory animals, including teratogenesis, hepatic steatosis, thymic atrophy, immune dysfunction and a lethal wasting syndrome [17]. The dose-dependent sensitivity to TCDD-induced toxicities varies widely among

• To confirm a role of OCT

  2025-03-03

  

  To confirm a role of OCT3 in corticosterone-induced potentiation of cocaine-primed reinstatement, we examined the interaction of corticosterone and cocaine in the reinstatement of cocaine conditioned place preference (CPP) in wild type mice, and transgenic OCT3-deficient mice. These mice express a

• To validate the identified phosphorylation sites in the mous

  2025-03-03

  

  To validate the identified phosphorylation sites in the mouse heart, we analyzed HEK 293T NS 1738 transfected with Adrb1 based on the hypothesis that protein residues phosphorylated both in vivo and in vitro are more likely to be physiologically relevant. All of the phosphorylation sites identified

• Compound mg was purified as an

  2025-03-03

  

  Compound 3 (29 mg) was purified as an amorphous, colourless powder. Molecular formula C20H28O4 was established by HRESIMS (Fig. S11) and corroborated with 1H and 13C NMR spectroscopic data (Table 1). IR spectrum showed bands for hydroxyl (3433 cm−1) and carbonyl (1686 cm−1) groups. 13C NMR spectrum

• NOXA a BH only protein

  2025-03-03

  

  NOXA, a BH3-only protein, is best known as a selective inhibitor of MCL-1, which is a highly expressed pro-survival protein in many human malignancies [30]. In addition, NOXA was recently proven to act as a direct activator via directly binding to BAX to induce apoptosis [31]. Given that its levels

• From a clinical utility standpoint this study

  2025-03-01

  

  From a clinical utility standpoint, this study showed that AR can be useful in the GATA3-positive tumor of unknown origin setting. Epidemiologically, in this setting, the top 2 diagnoses in the differential diagnosis are metastatic carcinoma of breast origin or urothelial origin [18]. Seven out of 1

• br Results br Discussion By using an unbiased proteomic scre

  2025-03-01

  

  Results Discussion By using an unbiased proteomic screen for xCT binding partners, followed by functional validation, we have made the surprising discovery that mTORC2 regulates amino Temsirolimus metabolism in tumor cells by phosphorylating serine 26 of the cystine-glutamate antiporter xCT on

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